PROJECTS
Scanning electron microscope image of a primary small airway epithelial cell (black and white surface) performing phagocytic engulfment of apoptotic eosinophils (pseudo-coloured red).
Apoptotic Eosinophil imaged using transmission electron microscopy. The image clearly shows nuclear condensation of the normally bi-lobed eosinophil nucleus.
H Ficolin binding to the type II alveolar adenocarcinoma cell line, A549.
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Dietary Isothiocyanates
Derived from cruciferous vegetables like broccoli dietary isothiocyanates have a burgeoning research portfolio. Primarily people have studied sulforaphane as an anti-cancer therapeutic at levels far above dietary attainable levels. We are assessing the immunomodulatory effects of several isothiocyanates, including sulforphane, at levels which can be found in the blood after eating a 100g of broccoli.
Hydrogen Sulfide and Hypoxia
Single-cell gene expression analysis reveals genetic associations masked in whole-tissue experiments. Wills QF, Livak KJ, Tipping AJ, Enver T, Goldson AJ, Sexton DW, Holmes C. Nat Biotechnol. 2013;31(8):748-52.
Methods for qPCR gene expression profiling applied to 1440 lymphoblastoid single cells. Livak KJ, Wills QF, Tipping AJ, Datta K, Mittal R, Goldson AJ, Sexton DW, Holmes CC. Methods. 2013;59(1):71-9.